Quick facts about chronic myeloid leukaemia
Chronic myeloid leukaemia (CML) starts when the bone marrow produces partly-mature white blood cells that grow and spread abnormally
The white blood cells that CML affect are called granulocytes. They are a type of myeloid blood cell that moves through a large network of tissues and organs called the lymphatic system and impact areas such as the lymph nodes, spleen and liver. When bone marrow produces too many granulocytes, they are called blasts or leukaemic blasts
Chronic leukaemia develops slowly and may take months or years for symptoms to develop
Overall, leukaemia accounts for 7% of all cancer cases in Malaysia. CML is an uncommon type of leukaemia that mainly affects adults
Types of chronic myeloid leukaemia
All cases of CML have a chromosomal abnormality called the Philadelphia chromosome. Your cells contain 23 chromosomes and the Philadelphia chromosome develops in chromosome 22 when part of chromosome 9 joins onto it. This new type of chromosome contains the BCR-ABL gene that tells leukaemia cells to grow and spread.
Signs and symptoms of chronic myeloid leukaemia
As signs and symptoms for CML can be similar to other common conditions, it’s important to see your GP or healthcare professional if you experience any of the symptoms below. In many cases, these symptoms may not show for months or years after developing CML. Discussing anything concerning as soon as possible can help give you peace of mind and offer the best chance of successful treatment if you receive an CML diagnosis.
Although CML has no symptoms in many cases and is often diagnosed during routine blood tests, symptoms may include:
Tiredness
Anaemia, including dizziness, paleness and shortness of breath
Night sweats
High temperature
Unexplained weight loss and loss of appetite
Bone pain
Enlarged abdomen and feeling full after eating a small amount
Increased bleeding and bruising
Stages of chronic myeloid leukaemia
Unlike other cancers, CML is classified into phases rather than stages. These phases are based on the number of immature white blood cells in your bone marrow and blood.
-
Chronic phase
This phase can last many years and is when most people are diagnosed. During this phase the blast cell (immature cells) numbers in the blood and bone marrow are low (< 5%), which means the phase is relatively stable. There are few (if any) symptoms in this stage.
-
Accelerated phase
During the accelerated phase, the number of blast cells start to increase in the bone marrow and blood.
-
Blast phase
The blast phase is a period of rapid progression where blast cell numbers in the blood and bone marrow increase quickly. Symptoms often worsen and the patient is considered to have a form of acute leukaemia.
Treatment for chronic myeloid leukaemia
There are many different types of treatment for chronic myeloid leukaemia. Your treatment will depend on you and your cancer.
Frequently asked questions about chronic myeloid leukaemia
Helpful resources
References
Make an appointment
Find out how to become a patient at Icon, or request more information from your nearest centre.
Enquire today
Our doctors
Icon brings together some of the region's most experienced medical oncologists, radiation oncologists and haematologists.
Learn more
